Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice
نویسندگان
چکیده
منابع مشابه
Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice.
Changes to innate cells, such as macrophages and myeloid-derived suppressor cells (MDSCs), during aging in healthy or tumor-bearing hosts are not well understood. We compared macrophage subpopulations and MDSCs from healthy young (6-8 weeks) C57BL/6J mice to those from healthy geriatric (24-28 months) mice. Spleens, lymph nodes, and bone marrow of geriatric hosts contained significantly more M2...
متن کاملTargeting glutamine metabolism rescues mice from late-stage cerebral malaria.
The most deadly complication of Plasmodium falciparum infection is cerebral malaria (CM) with a case fatality rate of 15-25% in African children despite effective antimalarial chemotherapy. There are no adjunctive treatments for CM, so there is an urgent need to identify new targets for therapy. Here we show that the glutamine analog 6-diazo-5-oxo-L-norleucine (DON) rescues mice from CM when ad...
متن کاملTargeted expression of a lumican transgene rescues corneal deficiencies in lumican-null mice.
PURPOSE To investigate whether targeted expression of lumican in the mouse cornea rescued the Lum(-/-) phenotype. METHODS Lum(-/-)/Kera-Lum mice were generated by crossing Lum(-/-) mice with Kera-Lum transgenic mice that overexpressed lumican under the control of the keratocan promoter. Mouse eyes were analyzed in vivo by confocal microscopy through focusing (CMTF) to determine corneal sublay...
متن کامل[DNA polymorphisms of the age-related gene in geriatric diseases].
老化の機序 を説明する場合, プログラム説 (遺伝 因子) とエラー蓄積説 (環境因子) の二大学説がある. プログ ラム説では, 老化は生殖の後 に進行する必然的な事柄で, 遺伝子 レベルであらかじめ決定されている過程であると する説である. エラー蓄積説は, 生体に対する紫外線な どの障害や老廃物の蓄積がDNAや 蛋白質に発生 し, 最 終的には致命的な障害 となるとする説である. この二つ の機構が互いに関連しながら老化は進むものと考えられ る. プログラム説を支持する事実としては, 遺伝的にそ の発症が規定されている早老症の存在がある. 多 くの遺 伝性早老症は特定の臓器の老化症状 を発現するため, 本 来の老化そのものを反映していないが, 原因となる遺伝 子を調べれば, 分子遺伝学的側面からの老化機構解明の 糸口になるものと期待 される. ウェルナー症候群 (WS) は遺伝...
متن کاملFight against glucose rescues Age-Related cognitive decline
Aging is commonly associated with dysfunctions of various systems, especially the cognitive decline that seriously diminishes the independence and life quality of old individuals. Exploring the approaches for maintaining a healthy brain is now a critical public health concern. Calorie restriction (CR) has been known to extend longevity, promote metabolic health, and delay the progress of aging ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Aging Cell
سال: 2013
ISSN: 1474-9718
DOI: 10.1111/acel.12062